China (Mainland)
High Purity Pharmaceutical grade 99% Pramipexole powder CAS NO.104632-26-0 Dihydrochloride CAS NO.104632-26-0
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- Min.Order: 10 Gram
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- Available Specifications:
1(1-10)Gram1(1-10)Gram10(1-10)Gram
- Product Details
Keywords
- Pramipexole
- 104632-26-0
- Dihydrochloride
Quick Details
- ProName: High Purity Pharmaceutical grade 99% P...
- CasNo: 104632-26-0
- Molecular Formula: C10H17N3S
- Appearance: white powder
- Application: bodybuilding, muscle building
- DeliveryTime: 5-8 days
- PackAge: exquisite or according to your require...
- Port: hongkong
- ProductionCapacity: 1000 Kilogram/Day
- Purity: 99%
- Storage: Sealed, dry, microtherm
- Transportation: DHL,TNT,FEDEX，HKEMS,UPS,etc
- LimitNum: 10 Gram
- Related Substances: 0
- Residue on Ignition: 0
- Heavy Metal: 0
- Valid Period: 0
- email: taigui-alice@hotmail.com
- skype: xu.alice55
Superiority
High Purity Pharmaceutical grade 99% Pramipexole powder CAS NO.104632-26-0 Dihydrochloride
description:
cas 104632-26-0
synonyms (s)-4,5,6,7-tetrahydro-n6-propyl-2,6-benzothiazolediamine;(s)-2-amino-6-propylamino-4,5,6,7-tetrahydrobenzthiazole;n'-propyl-4,5,6,7-tetrahydrobenzothiazole-2,6-diamine;pramipexol;(s)-2-amino-6-(propylamino)-4,5,6,7-tetrahydrobenzothiazoltetrahydrobenzothiazol;pramipexole: pramipexole dihydrochloride;pramipexol diclorohidrato monohidrato;
pramipexole 2hcl monohydrate
mf c10h17n3s
mw 211.324 g/mol
introduction:
why is this medication prescribed
pramipexole is used alone or with other medications to treat the symptoms of parkinson's disease (pd; a disorder of the nervous system that causes
difficulties with movement, muscle control, and balance), including shaking of parts of the body, stiffness, slowed movements, and problems with balance.
pramipexole is also used to treat restless legs syndrome (rls; a condition that causes discomfort in the legs and a strong urge to move the legs,
especially at night and when sitting or lying down).
Details
| product name: | pramipexole |
| other name: | (s)-4,5,6,7-tetrahydro-n6-propyl-2,6-benzothiazolediamine;(s)-2-amino-6-propylamino-4,5,6,7-tetrahydrobenzthiazole;n'-propyl-4,5,6,7-tetrahydrobenzothiazole-2,6-diamine;pramipexol;(s)-2-amino-6-(propylamino)-4,5,6,7-tetrahydrobenzothiazoltetrahydrobenzothiazol;pramipexole: pramipexole dihydrochloride;pramipexol diclorohidrato monohidrato;pramipexole 2hcl monohydrate; |
| original: | china |
| cas: | 104632-26-0 |
| molecular formula: | c10h17n3s |
| mw: | 211.33 |
| leading time | within 3 work days upon receipt of payment |
| delivery | fast and secure shipping by ems, dhl, tnt, fedex, ups |
| purity | 99% |
| package | discreet and hidden package according to specific requirement |
| appearance | white powder |
| certification | sgs, iso 9001, kosher |
| price | negotiable |
| usage | (s)-pramipexole enantiomer. s disease (pd) and restless legs syndrome (rls).[1] it is also sometimes used off-label as a treatment for cluster headache and to counteract the problems with sexual dysfunction experienced by some u sers of the selective serotonin reuptake inhibitor (ssri) antidepressants. |
| molecular structure |
|
description
pramipexole (mirapex, mirapexin, sifrol) is a dopamine agonist of the non-ergoline class indicated for treating parkinson's disease (pd) and restless legs syndrome (rls).
pramipexole has some of the same effects as a chemical called dopamine, which occurs naturally in your body. low levels of dopamine in the brain are associated with parkinson's disease.
only immediate-release pramipexole (mirapex) is approved to treat either parkinson symptoms or rls. extended-release pramipexole (mirapex er) is approved only to treat parkinson symptoms.
in a single controlled study of twenty one patients, pramipexole was found to be highly effective in the treatment of bipolar depression. treatment was initiated at 0.125 mg three times a day and increased at a rate of 0.125 mg three times a day to a limit of 4.5 mg daily until the patients' condition satisfactorily responded to the medication or they could not abide the side effects. the final average dosage was 1.7 ± 0.9 mg daily. the incidence of hypomania in the treatment group was no greater than in the control group, although the size of the study is too small to determine risks for manic switch.
application
pramipexole is used to treat symptoms of parkinson's disease (stiffness, tremors, muscle spasms, and poor muscle control). pramipexole is also used to treat restless legs syndrome (rls).
pramipexole also possesses low/insignificant affinity (500–10,000 nm) for the 5-ht1a, 5-ht1b, 5-ht1d, and α2-adrenergic receptors. it has negligible affinity (>10,000 nm) for the d1, d5, 5-ht2, α1-adrenergic, beta-adrenergic, h1, and mach receptors. all sites assayed were done using human tissues.
while pramipexole is used clinically (see below), its d3-preferring receptor binding profile has made it a popular tool compound for preclinical research. for example, pramipexole has been used (in combination with d2- and or d3-preferring antagonists) to discover the role of d3 receptor function in rodent models and tasks for neuropsychiatric disorders.
of note, it appears that pramipexole, in addition to having effects on dopamine d3 receptors, may also affect mitochondrial function via a mechanism that remains less understood. a pharmacological approach to separate dopaminergic from non-dopaminergic (e.g. mitochondrial) effects of pramipexole has been to study the effects of the r-stereoisomer of pramipexole (which has much lower affinity to the dopamine receptors when compared to the s-isomer) side-by-side with the effects of the s-isomer.
specification
| items | specifications | results |
| appearance | white or off-white powder | off-white powder |
| chemical purity (hplc) | ≥99.0% | 99.81% |
| optical purity(chiral hplc) | ≥99.0% | 99.95% |
| loss on drying | ≤ 1.0% | 0.43% |
| residue on ignition | ≤ 0.5% | 0.07% |
| heavy metals | ≤ 20ppm | < 10ppm |
| conclusion | analysis according to factory standards , conform | |